Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
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Neuropeptide Y Receptor Antagonists
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Neuropeptide Y Receptor Activators
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Neuropeptide Y Receptor Modulators
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Neuropeptide Y Receptor Control
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Neuropeptide Y Receptor Related Products (180)
Related Products (180)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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Galanin (swine) TFA
0 ImagesCat. No.: HY-P1128AGalanin (swine) TFA, a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) TFA is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
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NPY Y2 antagonist 1
0 ImagesNPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective neuropeptide Y receptor (NPY) Y2 antagonist.
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NNC0165-1273 acetate
0 ImagesCat. No.: HY-P11291BPurity: 99.78%NNC0165-1273 acetate is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 acetate blocks Ghrelin-induced cFos expression. NNC0165-1273 acetate reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 acetate reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 acetate can be used in studies related to diet-induced obesity.
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Npy2r Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09515Npy2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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BMS-193885 L-Lactic acid
0 ImagesCat. No.: HY-107727CAS No.: 679839-66-8BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition.
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[D-Trp34]-Neuropeptide Y TFA
![[D-Trp34]-Neuropeptide Y TFA](https://file.medchemexpress.com/product_pic/hy-p1322a.gif "Click to View [D-Trp34]-Neuropeptide Y TFA Product Detail")
0 ImagesCat. No.: HY-P1322A[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.
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CYM 9484 (Standard)
0 ImagesCat. No.: HY-107735RCAS No.: 1383478-94-1
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J-115814
0 ImagesCat. No.: HY-122021CAS No.: 329716-61-2J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.
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Galnon TFA (Standard)
0 ImagesCat. No.: HY-103536ARCAS No.: 1217448-19-5Galnon TFA (Standard) is the analytical standard of Galnon TFA (HY-103536A). This product is intended for research and analytical applications. Galnon TFA is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon TFA exhibits anticonvulsant and anxiolytic effects.
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L 152804 (Standard)
0 ImagesCat. No.: HY-107734RCAS No.: 6508-43-6L 152804 (Standard) is the analytical standard of L 152804 (HY-107734). This product is intended for research and analytical applications. L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
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S 25585 (Standard)
0 ImagesCat. No.: HY-107728RCAS No.: 263849-50-9
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NPY5RA-972 (Standard)
0 ImagesCat. No.: HY-107730RCAS No.: 439861-56-0NPY5RA-972 (Standard) is the analytical standard of NPY5RA-972 (HY-107730). This product is intended for research and analytical applications. NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor.
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HT-2157 (Standard)
0 ImagesCat. No.: HY-100717RCAS No.: 303149-14-6Synonyms: SNAP 37889 (Standard)
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BIIE-0246 (Standard)
0 ImagesCat. No.: HY-101986RCAS No.: 246146-55-4Synonyms: AR-H 053591 (Standard)BIIE-0246 (Standard) is the analytical standard of BIIE-0246 (HY-101986). This product is intended for research and analytical applications. BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
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BIBP3226 TFA (Standard)
0 ImagesBIBP3226 TFA (Standard) is the analytical standard of BIBP3226 (TFA) (HY-107726). This product is intended for research and analytical applications. BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.
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RF9 (Standard)
0 ImagesCat. No.: HY-107382RCAS No.: 876310-60-0RF9 (Standard) is the analytical standard of RF9 (HY-107382). This product is intended for research and analytical applications. RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
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GW438014A free base
0 ImagesCat. No.: HY-110107ACAS No.: 469861-48-1GW438014A free base is a selective NPY-Y5 receptor competitive antagonist capable of crossing the blood-brain barrier, with IC50 values of 197 nM and 211 nM against human receptors. GW438014A free base reverses PYY-mediated inhibition of Forskolin (HY-15371)-induced cAMP production, reduces NPY-induced food intake and nocturnal food intake in rodents, decreases body weight gain and fat mass in Zucker rats, and inhibits centrally mediated feeding behavior. GW438014A free base can be used in research related to obesity and epilepsy.
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BIBO3304 (Standard)
0 ImagesCat. No.: HY-107725RCAS No.: 191868-14-1BIBO3304 (Standard) is the analytical standard of BIBO3304 (HY-107725). This product is intended for research and analytical applications. BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
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FR252384
0 ImagesCat. No.: HY-U00335CAS No.: 447405-11-0FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
